The vertices of ΔPQR are P(2, 1), Q(–2, 3) and R(4, 5). Let S be the midpoint of PQ. So, S = $\left(\frac{-2+2}{2},\frac{3+1}{2}\right)$ = (0, 2) Equation of median RS is $\frac{y-5}{x-4}$ = $\frac{2-5}{0-4}$ ⇒ $\frac{y-5}{x-4}$ = $\frac{-3}{-4}$ ⇒ 4y - 20 = 3x - 12 ⇒ 3x – 4y + 8 = 0 is the required equation.