Concept:Mutation is a sudden, heritable change in the
DNA sequence.
Explanation:According to Hugo de Vries, mutations are large, random, and directionless.
They occur by saltation, meaning a single major change can produce a new trait.
Therefore, the statement that mutation is small and directional is wrong.
Options A, C, and D correctly describe mutation.
Answer:The incorrect option is B: According to Hugo de Vries, mutation is small and directional.