Concept:A proportion can be solved by cross multiplication.Explanation:Let the missing number be x.Then the given equation becomes x50​=1221​x​.First change the mixed fraction: 1221​=225​.So, x50​=225​x​.Cross multiply: 50×225​=x2.Simplify the left side: 25×25=625.Thus, x2=625.Taking the positive square root, x=625​=25.Verification: 2550​=2 and 225​25​=2.So the value satisfies the equation.Answer:The missing number is 25, which matches option D.