Concept:Itai-Itai is a bone disease caused by heavy metal poisoning from industrial pollution.Explanation:The disease was first identified in Japan in the 1960s.It is caused by cadmium (Cd) contamination from mining and industrial waste.Symptoms include osteomalacia (soft bones) and severe bone pain.Cadmium also leads to renal tubular failure.Note: Mercury causes Minamata disease, arsenic causes Blackfoot disease, and nitrate causes Blue baby syndrome.
