Concept:An empty set has no elements. Real numbers are those that can be plotted on the number line; imaginary numbers are not real.Explanation:The set S is defined by x2+1=0 with the condition that x is real.Solving x2+1=0 gives x2=−1.The square root of −1 is −1=i, where i is the imaginary unit.Thus x=±i, which are not real numbers.Since no real value of x satisfies the equation, the set S contains no elements.Therefore, S is an empty set.Answer:S is an empty set (Option D).