The vertices of ΔPQR are P(2, 1), Q(–2, 3) and R(4, 5).
Let S be the midpoint of PQ.
So, S = (

−2+2

2

,

3+1

2

) = (0, 2)

Equation of median RS is

y−5

x−4

=

2−5

0−4

⇒

y−5

x−4

=

−3

−4

⇒ 4y - 20 = 3x - 12
⇒ 3x – 4y + 8 = 0 is the required equation.