→ The infective stage of Plasmodium is sporozoite, which is present in the salivary glands of female Anopheles mosquito,enter the blood of the human being with the saliva of the mosquito. Once they reach the human body they leave the blood and infect the hepatic cells within an hour where they multiply by asexual multiple fission called schizogony → After repeated erythrocytic cycles in Plasmodium, some merozoites develop into sexually differentiated forms called gametocytes in the RBC to begin the gametogony. Their maturation takes place in spleen and bone marrow.