Lysergic Acid Diethylamide (LSD) is one of the most potent, mood-changing chemicals. It is manufactured from lysergic acid, which is found in the ergot fungus that grows on rye and other grains. It stimulates serotonin production in the cortex and deep structures of the brain, by activating serotonin receptors. It can be given to patients suffering with depression and insomnia.