(c) : Plasmodium is a tiny protozoan which is responsible for malaria in the human. In malaria the patient experiences high fever which periodically rises and also experiences recurring chills with fever. Such symptoms are seen because when the RBCs carrying Plasmodium (one of the stage in the life cycle of the parasite) ruptures it releases a toxic substance called haemozoin which is chiefly responsible for the chill and high fever recurring every three to four days.