• Streptokinase is produced by Streptococcus and is used as a clot buster for removing clots from the blood vessels of patients who have undergone myocardial infarction leading to heart attack. • Cyclosporin A, that is used as an immuno-suppressive agent in organ-transplant patients, it is produced by the fungus Trichoderma polysporum • Statins produced by Monascus purpureus have been commercialized as blood-cholesterol lowering agent. • Citric acid is produced by Aspergillus niger