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PASSAGE IV Experiments with the Sulphonamides have made clear a fact about germs which is gaining increasing importance in fighting them. Germs, it seems, have the same ability as all the other living things gradually to change themselves to suit new conditions. But, as the generation of germs lasts only twenty, twenty five or thirty minutes, before all the germs divide to form new ones, changes that would take many years in animals can be achieved by germs in a few hours. Perhaps, then you give the attacking germ a dose of Sulphonamides which upsets them somewhat but is not strong enough to prevent them from multiplying; if so, they very rapidly develop new powers which enable them to resist the effects of the drug. After this, has happened, even the strongest dose will fail to disturb them.
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