● Option 1 is incorrect since it is difficult to envisage how this can be achieved because it is one thing to create an artificial chromosome and quite another to to make it functional. ● Option 2 is Artificial Gene Synthesis whereas Option 4 is Plant and Animal Tissue Culture Technology. ● Option 3 is Cloning. ● Artificial gene synthesis, sometimes known as DNA printing is a method in synthetic biology that is used to create artificial genes in the laboratory. ● The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs