Both manuscript and inscription refer to two kinds of letters between which there is some difference in the way they have been written. Inscription is a piece of material, which is inscribed. The letters in the particular material is engraved or carved into it. A coin is a goodexample for an inscribed object. On the other hand, manuscript is any document written by hand. Authors, usually write their pieces of work in papers before sending them for printing. This original,handwritten texts are considered to be manuscripts