Concept:For a 2×2 determinant acbd, its value is ad−bc.To maximize the value, choose the largest possible numbers for a and d and the smallest possible for b and c.Explanation:All prime numbers less than 20 are: 2,3,5,7,11,13,17,19.We need four different primes for p,q,r,s in prqs.The determinant is ps−qr.To maximize ps−qr, assign the two largest primes (19 and 17) to p and s, and the two smallest primes (2 and 3) to q and r.One such assignment is p=17, q=2, r=3, s=19.Thus, the determinant becomes 17×19−2×3=323−6=317.Any other arrangement using these same four numbers gives the same value because ps−qr is unchanged when swapping p with s or q with r.Hence, the maximum possible determinant is 317.Answer:317